期刊
JOURNAL OF VIROLOGY
卷 74, 期 15, 页码 6748-6759出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.74.15.6748-6759.2000
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资金
- NIAID NIH HHS [AI-15608, AI-37293, R01 AI037293, R37 AI015608, R01 AI015608, AI-28317] Funding Source: Medline
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that persistently infects 85% of the adult population worldwide. In this report, we examine the proliferative response and cytokine secretion profile of CD4(+) T lymphocytes from a panel of unrelated EBV-positive donors against two EBV latent antigens, EBNA1 and EBNA3C. Substantial proliferative responses by CD4(+) lymphocytes mere demonstrated to both antigens in multiple, randomly selected donors. Surprisingly, we observed a striking and consistent difference in cytokine response to EBNA1 and EBNA3C. EBNA1-specific CD4(+) T lymphocytes from multiple unrelated donors preferentially produced type 2-like cytokines in response to antigenic stimulation, while the response to EBNA3C was a characteristic type 1 response, The implications of these findings for EBV persistence and the development of EBV-associated malignancies are discussed.
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