期刊
HEPATOLOGY RESEARCH
卷 18, 期 2, 页码 104-109出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S1386-6346(99)00088-1
关键词
glutathione; chronic hepatitis; viral hepatitis; liver
The aim of this study was to evaluate the effects of hepatitis B and C virus infections on liver glutathione status. Reduced and oxidized glutathione levels were determined in liver biopsy specimens obtained from patients with chronic liver disease including chronic active hepatitis and cirrhosis. In patients with hepatitis B virus infections, GSH and GSH/GSSG levels were significantly low compared with those in controls (P < 0.01). There was a significant negative correlation between histological activity indices (HAI) and hepatic GSSG levels only in patients with chronic HCV infection (P < 0.01; r = -0.895). In addition to this, we also found a positive correlation between indices (HAI) and GSPI/GSSG of the same group (r = 0.915; P < 0.05). These observations suggest that HBV and HCV infections have different effects on liver glutathione status based on diverse mechanisms. (C) 2000 Elsevier Science Ireland Ltd, All rights reserved.
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