期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 38, 期 8, 页码 2998-3003出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.38.8.2998-3003.2000
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- NIAID NIH HHS [AI29040, R21 AI029040, R01 AI029040] Funding Source: Medline
Bovine mastitis caused by Staphylococcus aureus is responsible for major economic losses to the dairy industry, and more-effective therapeutic or preventive approaches are sorely needed, The predominance of staphylococcal capsular polysaccharide types 5 and 8 among human isolates from many sources is well documented, but there seems to be a greater variation in the distribution of capsular serotypes among isolates from cows. A total of 636 isolates of S, aureus from cases of bovine mastitis in Sweden, Denmark Finland, Iceland, ireland, and the United States were investigated for production of capsular polysaccharide types 5 and 8, Approximately half of all the European isolates tested were of serotype 8, although variation among countries and among isolates of clinical and subclinical origin was observed. Sweden had the highest frequency (87%) of serotypeable isolates, and Finland had the lowest (48%). Capsule types 5 and 8 accounted for only 42% of the U.S. isolates tested. A few isolates showed weak reactivity with CP5 antiserum in a colony blot assay, and an enzyme-linked immunosorbent assay inhibition method confirmed that the levels of capsule produced by these strains were <10% of those produced by control strains. fifty isolates that failed to react with capsular antisera all possessed the genes for production of capsular polysaccharide type 5 or 8, These results underscore the variability in capsule production by bovine isolates of S. aureus from different geographic regions. This information is important for the rational design of a capsule-based vaccine to prevent S, aureus bovine mastitis.
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