期刊
CELL DEATH AND DIFFERENTIATION
卷 7, 期 8, 页码 739-746出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cdd.4400705
关键词
apoptosis; cytoprotectant; flow cytometry; hepatocyte; hepatoma; hepatotoxin
The protein phosphatase-inhibitory algal toxins, okadaic acid and microcystin-LR, induced overphosphorylation of keratin and disruption of the keratin cytoskeleton in freshly isolated rat hepatocytes. In hepatocyte cultures, the toxins elicited DNA fragmentation and apoptotic cell death within 24 h. All these toxin effects could be prevented by the grapefruit flavonoid, naringin. The cytoprotective effect of naringin was apparently limited to normal hepatocytes, since the toxin-induced apoptosis of hepatoma cells, rat or human, was not prevented by the flavonoid.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据