期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 108, 期 1-2, 页码 227-235出版社
ELSEVIER
DOI: 10.1016/S0165-5728(00)00285-X
关键词
chemokine receptor; CXCR3; IP-10; MIP-1 beta; Alzheimer's disease; CNS
资金
- NIA NIH HHS [P50AG05134] Funding Source: Medline
Inflammatory mediators have been implicated in the pathophysiology of neurodegenerative diseases. Here we report the presence of the chemokine receptor CXCR3 and its ligand, IP-10, in normal and Alzheimer's disease (AD) brains. CXCR3 was detected constitutively on neurons and neuronal processes in various cortical and subcortical regions; IP-10 was observed in a subpopulation of astrocytes in normal brain, and was markedly elevated in astrocytes in AD brains. Many IP-10(+) astrocytes were associated with senile plaques and had an apparently coordinated upregulation of MIP-1 beta. Moreover, we showed that CXCR3 ligands, IP-10 and Mig, were able to activate ERK1/2 pathway in mouse cortical neurons, suggesting a novel mechanism of neuronal-glial interaction. (C) 2000 Elsevier Science B.V. All rights reserved.
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