期刊
BRITISH JOURNAL OF CANCER
卷 83, 期 3, 页码 360-365出版社
NATURE PUBLISHING GROUP
DOI: 10.1054/bjoc.2000.1261
关键词
prostate cancer; endothelin-1; bone lesions
类别
The causes for the propensity of metastasized prostate cancer cells to grow in bone and to induce osteoblastic lesions remain unresolved. Go-culture of human prostate cancer cell lines with bone slices was determined to increase the level of endothelin-l (ET-1) mRNA and its production. ET-1 is an ejaculate protein that also stimulates osteoblasts. Osteoclastic bone resorption was significantly blocked by the presence of androgen-independent prostate cancer cells in a dose-dependent manner as that of synthetic ET-1, The inhibition could be neutralized by specific ET-1 antibody. indicating the association of prostate cancer-derived ET-1 with inhibition of bone resorption. The combined ET-1 activity on osteoclasts and osteoblasts disrupts bone remodelling. ET-1 production is also elevated in the presence of prostate-specific antigen (PSA), ET-1 in turn enhances DNA synthesis of prostate cancer cells. Interactions among cancer cells, bone, ET-1 and PSA may be critical in cancer growth and lesions in bone. (C) 2000 Cancer Research Campaign.
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