期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 274, 期 2, 页码 410-414出版社
ACADEMIC PRESS INC
DOI: 10.1006/bbrc.2000.3144
关键词
dipeptidyl peptidase IV (DP IV, CD26); TGF-beta(1); T-cell; quantitative RT-PCR
Stimulation of human T-cells by pokeweed mitogen (PWM) results in a significant increase of IL-2, IFN-gamma, and DP IV mRNA expression as analyzed by quantitative RT-PCR. Here we show for the first time that the changes observed in cytokine mRNA expression are dose-dependently suppressed by the specific dipeptidyl peptidase TV inhibitor Lys[Z(NO2)]-thiazolidide. Most interestingly, the inhibition of DP IV activity leads to a decrease in mRNA expression of the enzyme itself. Furthermore, evidence is provided that this suppression is mediated by TGF-beta(1). The presented data fit into the hypothesis that inhibition of DP IV leads to the induction of TGF-beta(1), which in turn provokes an arrest of cell cycle in late G(1). (C) 2000 Academic Press.
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