期刊
BRAIN RESEARCH
卷 873, 期 1, 页码 165-167出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(00)02520-8
关键词
obesity; blood-brain barrier; influx; ob/ob; db/db
资金
- NIDDK NIH HHS [R01-DK54880] Funding Source: Medline
- NIMH NIH HHS [R01-MH54979] Funding Source: Medline
- NINDS NIH HHS [5-F32-NS10504-02] Funding Source: Medline
In lean CD-1 mice, leptin is delivered into the brain by a saturable transport mechanism. Previous work has shown that obesity is associated with decreased leptin transport. Here, we investigated the transport of leptin across the blood-brain barrier (BBB) in two murine models of obesity. Radioiodinated leptin was intravenously injected into ob/ob (no leptin production) and db/db thigh leptin levels, but no long-form leptin receptor) mutant mice and their lean controls. In all groups, the labeled polypeptide was transported across the BBB by a saturable mechanism. The rates of transport were not significantly different between the mutant strains and their lean controls. The results demonstrate that leptin transport persists in the absence of production of the endogenous polypeptide or its signal-transducing receptor and suggest that the impaired transport previously seen is not directly explained by only obesity or alterations in serum plasma levels. (C) 2000 Elsevier Science B.V. All rights reserved.
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