Synthetic studies on the DEF ring system of ristocetin A via ruthenium-promoted SNAr reaction:: problems and solutions using arylserine-Ru complexes

Ruthenium-promoted intramolecular SNAr reaction has allowed the construction of the 16-membered DEF model macrocycle of ristocetin A that incorporates the required arylserine residue as the E ring. (C) 2000 Elsevier Science Ltd. All rights reserved.