Synthesis of aminophosphonate haptens for an aminoacylation reaction between methyl glucoside and a β-alanyl ester

Two 2-aminophosphonate haptens derived from methyl alpha-D-glucopyranoside were synthesized to mimic the transition-state of a transesterification reaction between methyl alpha-D-glucopyranoside and 3-nitrophenylester of tert-BOC-beta-alanine. Two sets of monoclonal antibodies were generated against these haptens. (C) 2000 Elsevier Science Ltd. All rights reserved.