期刊
CARBOHYDRATE RESEARCH
卷 327, 期 4, 页码 455-461出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0008-6215(00)00059-8
关键词
hyaluronan; TEMPO; oxidation kinetics; IR spectroscopy
2,2,6,6-Tetramethyl-1-piperidinyloxy radical (TEMPO)-mediated oxidation of hyaluronan was studied at pH 10.2. and temperature of 0 degrees C with NaOCl as the primary oxidant. As with other polysaccharides, a high selectivity of oxidation was observed. The degradation of the polymer was essentially caused by the oxidation process. The primary oxidant and the pH of the reaction mixture did not alter the molecular weight of hyaluronan during oxidation. The kinetics of the oxidation process was investigated at different concentrations of reactants and the inorganic salts, NaBr, NaCl, and Na2SO4. An increase in the salt concentration in the mixture causes a major decrease in the rate of the oxidation, and this decrease is independent of the nature of the salt. (C) 2000 Elsevier Science Ltd. All rights reserved.
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