期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
卷 1459, 期 2-3, 页码 383-389出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0005-2728(00)00175-4
关键词
mitochondria; uncoupling protein; fatty acid; nucleotide; ion transport; reconstitution
资金
- NIDDK NIH HHS [DK56273] Funding Source: Medline
- NIGMS NIH HHS [GM31086] Funding Source: Medline
According to the proton buffering model, introduced by Klingenberg, UCP1 conducts protons through a hydrophilic pathway lined with fatty acid head groups that buffer the protons as they move across the membrane. According to the fatty acid protonophore model, introduced by Garlid, UCPs do not conduct protons at all. Rather, like all members of this gene family, they are anion carriers. A variety of anions are transported, but the physiological substrates are fatty acid (FA) anions. Because the carboxylate head group is translocated by UCP, and because the protonated FA rapidly diffuses across the membrane, this mechanism permits FA to behave as regulated cycling protonophores. Favoring the latter mechanism is the fact that the head group of long-chain alkylsulfonates, strong acid analogues of FA, is also translocated by UCP. (C) 2000 Elsevier Science B.V. All rights reserved.
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