期刊
BIOLOGICAL PSYCHIATRY
卷 48, 期 4, 页码 315-318出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0006-3223(00)00243-2
关键词
anorexia nervosa; bulimia nervosa; oxytocin; vasopressin; major depression; obsessive-compulsive disorder
Background: When ill, people with eating disorders have disturbances of the neuropeptides vasopressin and oxytocin. Methods: To avoid the confounding effects of the ill state, we studied women who were recovered (more than 1 year, normal weight, and regular menstrual cycles, no bingeing or purging) from bulimia nervosa (rBN) or binge eating/purging-type anorexia nervosa (rAN-BN), and matched healthy control women, Results: Vasopressin was elevated in rAN-BN and showed a trend rewards elevation in rBN. In rBN, elevated cerebrospinal fluid vasopressin may be related to having a lifetime history of major depression. In comparison, cerebrospinal fluid oxytocin was normal in recovered subjects, but elevated levels in some rBN might be related to birth control pill use. Conclusions: These data confirm and extend the possibility that elevated cerebrospinal fluid vasopressin may be related to the pathophysiology of eating disorders, and/or a lifetime history of major depression, (C) 2000 Society of Biological Psychiatry.
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