期刊
CELL
卷 102, 期 4, 页码 451-461出版社
CELL PRESS
DOI: 10.1016/S0092-8674(00)00050-7
关键词
-
资金
- NEI NIH HHS [EY06769] Funding Source: Medline
- NIAMS NIH HHS [AR42998] Funding Source: Medline
- NIDDK NIH HHS [DK39753] Funding Source: Medline
The location of follicular and epidermal stem cells in mammalian skin is a crucial issue in cutaneous biology. We demonstrate that hair follicular stem cells, located in the bulge region, can give rise to several cell types of the hair follicle as well as upper follicular cells. Moreover, we devised a double-label technique to show that upper follicular keratinocytes emigrate into the epidermis in normal newborn mouse skin, and in adult mouse skin in response to a penetrating wound. These findings indicate that the hair follicle represents a major repository of keratinocyte stem cells in mouse skin, and that follicular bulge stem cells are potentially bipotent as they can give rise to not only the hair follicle, but also the epidermis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据