期刊
NEUROSCIENCE LETTERS
卷 290, 期 1, 页码 79-83出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(00)01323-9
关键词
allodynia; hyperalgesia; thalamus; neurotoxic lesion; central pain syndrome
Damage to the ventral-posterior lateral nucleus (VPL) of the thalamus or its afferent pathways can produce moderate to severe on-going pain and pain in response to normally innocuous stimuli (allodynia) and hypersensitivity to mildly noxious stimuli (hyperalgesia). The present study measured the responses to mechanical and thermal stimuli before and 2, 8, 24 and 48 h after a kainate-induced lesion of the VPL in ma le rats. Com pared with control animals, hypersensitivity to mechanical stimulation of the hindpaw was apparent by 24 h post-lesion. At 48 h, the frequency of mechanical response increased from a baseline response frequency of 17 +/- 4.7 to 46 +/- 11.6%. Thermal withdrawal latencies 48 h after the lesion decreased from a baseline latency of 9.9 +/- 1.8 to 5.3 +/- 0.4 s. It is concluded that a neurotoxic lesion of the VPL results in a delayed onset of mechanical and thermal hyperalgesia. This study suggests a potential model for studying the basic mechanisms and potential therapies for central pain syndrome. (C) 2000 Published by Elsevier Science Ireland Ltd.
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