期刊
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
卷 141, 期 7, 页码 1301-1309出版社
SPRINGER
DOI: 10.1007/s00432-015-1929-y
关键词
Liver; Hepatocellular carcinoma; RapidArc; Stereotactic body radiation therapy
类别
To evaluate the feasibility and efficacy of stereotactic body radiation therapy (SBRT) in the treatment of hepatocellular carcinoma (HCC) unsuitable for standard loco-regional therapies. Patients with 1-3 inoperable HCC lesions with diameter a parts per thousand currency sign6 cm were treated by SBRT. According to lesions size and liver function, two prescription regimens were adopted: 48-75 Gy in three fractions or 36-60 Gy in six fractions. SBRT was delivered using the volumetric modulated arc therapy technique with flattening filter-free photon beams. The primary end points of this study were in-field local control (LC) and toxicity. Secondary end points were overall survival (OS) and progression-free survival (PFS). Forty-three patients with 63 HCC lesions were irradiated. All patients had Child-Turcotte-Pugh class A or B disease. Thirty lesions (48 %) were treated with 48-75 Gy in three consecutive fractions, and 33 (52 %) received 36-60 Gy in six fractions. Median follow-up was 8 months (range 3-43 months). Actuarial LC at 6, 12 and 24 months was 94.2 +/- A 3.3, 85.8 +/- A 5.5 and 64.4 +/- A 11.5 %, respectively. A biological equivalent dose (BED) > 100 Gy and GTV size were significant prognostic factors for LC in univariate analysis (p < 0.001 and p < 0.02). Median OS was 18.0 +/- A 5.8 months. Actuarial OS at 6, 12 and 24 months was 91.1 +/- A 4.9, 77.9 +/- A 8.2 and 45.3 +/- A 14.0 %, respectively. Univariate analysis showed that OS is correlated with LC (p < 0.04), BED > 100 (p < 0.05) and cumulative gross tumor volume GTV < 5 cm (p < 0.04). Median PFS was 8 months, with a 1-year PFS rate of 41 %. A significant (a parts per thousand yengrade 3) toxicity was observed in seven patients (16 %) 2-6 months after the completion of the treatment. No classic radiation-induced liver disease was observed. Stereotactic body radiation therapy is a safe and effective therapeutic option for HCC lesions unsuitable to standard loco-regional therapies, with acceptable local control rates and low treatment-related toxicity. The significant correlation between LC and higher doses and between LC and OS supports the clinical value of SBRT in these patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据