期刊
ONCOGENE
卷 19, 期 36, 页码 4184-4189出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1203761
关键词
cell cycle; lymphocyte; IL-2; cdk2; MAP kinase; nuclear localization
Cell proliferation is controlled by cdk2 which in association with cyclin E and a regulates G1/S transition and S phase progression. cdk2 activation is dependent on its localization in the nucleus where regulatory mediators are found, We report that activation of cdk2 is associated with the formation of cdk2/MAP kinase complexes, cdk2 associates with both inactive and activated MAP Kinase. Prevention of MAP Kinase activation ba the MEK inhibitor PD98059 inhibits both activation and nuclear localization of cdk2 and S phase entry. These findings indicate that the nuclear translocation of cdk2 is associated with the formation of molecular complexes containing active MAP Kinase and is dependent on MAP Kinase activation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据