期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 402, 期 3, 页码 251-254出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(00)00498-2
关键词
prepulse inhibition; apomorphine; phencyclidine; sigma 1 receptor ligand; MS-377
To evaluate the antipsychotic property of a sigma(1) receptor ligand, (R)-(+)-1-(4-chlorophenyl)-3-{4-(2-methoxyethyl)piperazin-1- yl}methyl-2-pyrrolidinone-L-tartrate (MS-377), an antagonistic effect of MS-377 on the disruption of prepulse inhibition (PPI) of the acoustic startle by apomorphine or phencyclidine (PCP) was investigated in rats. MS-377 antagonized the PCP-induced disruption of PPI. The ED50 value of MS-377 for this effect was 0.66 mg/kg. In contrast, apomorphine-induced disruption of PPI was not attenuated by MS-377. These data indicate that the PCP-induced disruption of PPI in rats would be, at least partially, mediated by sigma receptors and MS-377 could be a novel anti-psychotic agent with clinical efficacy for the sensorimotor-gating deficit in schizophrenia. (C) 2000 Elsevier Science B.V. All rights reserved.
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