期刊
CANCER LETTERS
卷 157, 期 1, 页码 31-38出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3835(00)00470-5
关键词
caffeic acid phenethyl ester; gap junctional intercellular communication; transformation by ras oncogene
类别
资金
- NCI NIH HHS [CA21104] Funding Source: Medline
Caffeic acid phenethyl ester (CAPE), an active ingredient of honeybee propolis, has been identified as having anti-inflammatory, anti-viral and anti-cancer properties. Since the deficiency of gap junctional intercellular communication (GJIC) has been shown to be a characteristic of most cancer cells, this study was designed to test the hypothesis that the anti-carcinogenic activity of CAFE might be related to its ability to restore GJIC in tumorigenic GJIC-deficient cells (WB-ras2 cells). The results showed that CAFE restored GJIC, phosphorylation of connexin 43 (Cx43) and its normal localization on the plasma membrane in WB-ras2 cells after 3 days at 5 mug/ml concentration. Additionally, CAFE inhibited growth in soft agar and decreased the protein level of p21(ras). The results are consistent with the hypothesis that the anti-cancer mechanism of CAFE may be mediated by its ability to restore GJIC. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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