期刊
JOURNAL OF MEDICAL GENETICS
卷 37, 期 9, 页码 680-683出版社
BRITISH MED JOURNAL PUBL GROUP
DOI: 10.1136/jmg.37.9.680
关键词
club foot; New Zealand Maori; complex segregation analysis
The role of major gene and multifactorial inheritance in the aetiology of club foot in the New Zealand Polynesian population was studied using 287 New Zealand Maori and Pacific club foot families. The club foot family data were analysed by complex segregation analysis under the mixed model using the computer program POINTER. This analysis shows that the best genetic model for club foot in this population is a single dominant gene with a penetrance of 33% and a predicted gene frequency of 0.9%. These data provide a scientific foundation for molecular studies in the Maori and Polynesian population to identify putative club foot genes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据