期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 44, 期 9, 页码 2581-2584出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.44.9.2581-2584.2000
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资金
- NIAID NIH HHS [AI35257, R01 AI035257] Funding Source: Medline
The mutant prevention concentration (MPC) of a C-8-methoxy fluoroquinolone exhibited a narrow distribution for 14 genetically diverse clinical isolates of Mycobacterium tuberculosis, indicating that results from single-isolate studies are likely to be representative. When one isolate was challenged with a variety of antituberculosis agents, C-8-methoxy fluoroquinolones were exceptional in having MPCs below the maximum concentration attained in serum by use of commonly recommended doses.
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