期刊
FARMACO
卷 55, 期 9-10, 页码 596-602出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/S0014-827X(00)00079-3
关键词
aminopyrazoles; pyrazolo[1,5-a[pyrimidines; sulfonamides and antibacterial activity
Hydrazones 2a-d were prepared from diazotiazation of sulfanilamide or its derivatives followed by coupling with ethyl cyanoacetate. 3-Aminopyrazoles 3a-d were obtained by refluxing of 2a-d with hydrazine hydrate in ethanol. [Bis(methylthio)methylene]malononitrile (4) was reacted with aminopyrazoles 3a-d in reflexing DMF containing triethyIamine to yield the novel pyrazolo[1,5-a]pyrimidines 6a-d. The anilino derivatives 8a-h were obtained by fusion of compounds 6a-d with aromatic amines. When compounds 6a,c,d were subjected to the reaction with hydrazine hydrate, the hydrazino derivatives 9a-c were isolated. Also, the aminopyrazoles 3 were reacted with some electrophiles such as arylidenemalononitriles, ethoxymethylene malononitrile and ethyl ethoxymethylene cyanoacetate to yield the novel substituted pyrazolo[1,5-alpyrimidines 13, 17 and 19, respectively. Structures of the new compounds were established by their elemental analyses and spectral data. Most of these compounds were also tested in vitro for their antibacterial activity against some Gram positive and Gram negative bacteria. (C) 2000 Published by Elsevier Science S.A. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据