期刊
CRITICAL CARE MEDICINE
卷 28, 期 9, 页码 S49-S56出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00003246-200009001-00011
关键词
protein C; activated protein C; sepsis; coagulation; inflammation; prognostic indicator
Objective: To consider the appropriateness of protein C levels as a prognostic indicator for sepsis and related diseases. Data Sources/Study Selection: Published research and review articles related to protein C deficiency in patients with sepsis and related diseases. Data Extraction and Synthesis: All applicable data were extracted, and relevant literature was cited to support factual statements in the text. The protein C pathway represents one of the major regulatory systems of hemostasis, exhibiting antithrombotic, profibrinolytic, and anti-inflammatory properties. Numerous studies have shown that acquired protein C deficiency is prevalent in the majority of septic patients (>85%) and is associated with increased morbidity and mortality in patients with severe sepsis and septic shock. This deficiency in protein C is not simply a transient marker for sepsis, but parallels the progress of the disease. In addition, protein C deficiency occurs in the presence of a wide range of pathogens and develops early in the disease process. Conclusions: A review of tbe relevant literature suggests that protein C levels may serve as a useful prognostic indicator of outcome in sepsis and related diseases.
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