期刊
JOURNAL OF VIROLOGY
卷 74, 期 18, 页码 8582-8588出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.74.18.8582-8588.2000
关键词
-
类别
资金
- NCI NIH HHS [P01 CA050661, R35 CA44343, P01 CA50661, 5T32CA72320, T32 CA072320] Funding Source: Medline
The mechanism by which murine polyomavirus penetrates cells and arrives at the nucleus, the site of viral replication, is not well understood. Simian virus 40 and JC virus, two closely related members of the polyomavirus subfamily, use caveola- and clathrin-mediated uptake pathways for entry, respectively. The data presented here indicate that compounds that block endocytosis of both caveola- and clathrin derived vesicles have no effect on polyomavirus infectivity. Polyomavirus does not appear to colocalize with either clathrin light chain or caveolin-1 by immunofluorescence microscopy, Additionally, expression of a dominant-negative form of dynamin I has no effect on polyomavirus uptake and infectivity. Therefore, polyomavirus uptake occurs through a class of uncoated vesicles in a clathrin-, caveolin-1-, and dynamin I-independent manner.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据