期刊
BIOLOGICAL PSYCHIATRY
卷 48, 期 5, 页码 406-414出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0006-3223(00)00930-6
关键词
schizophrenia; conditional associative learning; memory; context
资金
- NIMH NIH HHS [MH40279] Funding Source: Medline
Background: We adapted visual conditional associative learning paradigms to assess the contextual processing deficit model of schizophrenic cognitive impairment proposed by J.D. Cohen and D. Servan-Schreiber in 1992. In this task subjects learn the associations between four sets of stimuli through the use of feedback. We administered two experimental conditional associative learning conditions: in one, the eight stimuli used to make Sour pairs were all different; in the other, the pairs were made from different combinations of four identical stimuli, requiring the use of contextual information to mediate correct performance. Two additional associative learning tasks were administered where subjects generated the stimulus pairings or observed the experimenter form the pairs, eliminating the need to learn from feedback. Methods: We tested 37 patients with schizophrenia and 20 healthy control subjects in each conditional associative learning task condition. Results: Patients demonstrated significant impairments on all four conditional associative learning tasks. The demand to process contextual information did not differentially impact patient performance. Patients were better able to learn associations if they generated or observed the pairings rather than utilized feedback to guide learning. Conclusions: Patients with schizophrenia demonstrate pronounced deficits in the ability to utilize feedback to guide learning. We found no evidence of an additional deficit in processing of contextual information. (C) 2000 Society of Biological Psychiatry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据