期刊
TETRAHEDRON LETTERS
卷 41, 期 36, 页码 6993-6996出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(00)01195-3
关键词
4H-chromene; cyclization; Bcl-2 protein; apoptosis; anti-cancer agents
Substituted 4H-chromene derivatives are a new class of compounds that bind Bcl-2 protein and induce apoptosis in tumor cells. Here we report an efficient synthetic method for the preparation of these compounds from salicylaldehyde derivatives and alkyl cyanoacetates under solid-phase catalysis. (C) 2000 Elsevier Science Ltd. All rights reserved.
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