Natural product derived inhibitors of lipoprotein associated phospholipase A2, synthesis and activity of analogues of SB-253514

The synthesis of analogues of SB-253514, a novel natural product derived inhibitor of lipoprotein associated phospholipase A(2) (Lp-PLA(2)), is described together with their ability to inhibit Lp-PLA(2). (C) 2000 Elsevier Science Ltd. All rights reserved.