期刊
NEUROSCIENCE LETTERS
卷 291, 期 1, 页码 25-28出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(00)01383-5
关键词
paw pressure; paradoxial sleep deprivation; pain
The aim of this study was to assess the effect of paradoxical sleep deprivation (PSD) and sleep recovery on the vocalization threshold in rats submitted to a mechanical noxious stimulus. Sixteen male Wistar rats were randomly assigned in two groups: controls (n = 8), paradoxical sleep deprived rats (n = 8). PSD was performed using the 'inverted flower pot' technique. Paw pressure test was used to assess the sensitivity to mechanical noxious stimulus (vocalization threshold). The experiment was divided into three periods: baseline (day 1, day 2), PSD (day 3, day 4, day 5) and recovery (day 6, day 7, day 8, day 9). After 48 and 72 h of PSD, the vocalization thresholds decreased significantly in comparison to the control rats (day 4: 245 +/- 21 vs. 303 +/- 20 g, P = 0.05; day 5: 256 +/- 17 vs. 324 +/- 22 g, P = 0.02). In PSD group, relative to controls, vocalization thresholds increased significantly after 48, 72, and 96 h of recovery sleep periods (day 7: 378 +/- 24 vs. 307 +/- 8 g P = 0.01; day 8: 384 +/- 27 vs. 316 +/- 23 g, P = 0.02; day 9: 395 +/- 24 vs. 328 +/- 15 g, P = 0.02). Vocalization thresholds on day 6 were not significantly different in both groups (375 +/- 20 vs. 324 +/- 24 g, P = 0.08). In conclusion, experimental PSD in rats induces a significant decrease in vocalization threshold to mechanical noxious stimulus, which is totally reversed during the sleep recovery period. (C) 2000 Published by Elsevier Science Ireland Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据