期刊
GENES & DEVELOPMENT
卷 14, 期 18, 页码 2277-2282出版社
COLD SPRING HARBOR LAB PRESS
DOI: 10.1101/gad.827500
关键词
mitotic checkpoint; kinetochore; chromosome missegregation; mouse transgenic
Bub3 is a conserved component of the mitotic spindle assembly complex. The protein is essential for early development in Bub3 gene-disrupted mice, evident from their failure to survive beyond day 6.5-7.5 postcoitus (pc). Bub3 null embryos appear normal up to day 3.5 pc but accumulate mitotic errors from days 4.5-6.5 pc in the form of micronuclei, chromatin bridging, lagging chromosomes, and irregular nuclear morphology. Null embryos treated with a spindle-depolymerising agent fail to arrest in metaphase and show an increase in mitotic disarray. The results confirm Bub3 as a component of the essential spindle checkpoint pathway that operates during early embryogenesis.
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