期刊
FEBS LETTERS
卷 481, 期 2, 页码 159-163出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)02005-6
关键词
Gas1; p53 protein; GPI anchor; domain requirement; signal transduction
The product of the growth arrest specific gene, gas1, is a membrane-associated protein which activates a p53-dependent growth suppression signalling pathway. We have shown that Gas1 is linked to the plasma membrane through a glycosyl-phosphatidylinositol (GPI) anchor, Several GPI-anchored protein have been identified as part of receptor complexes either as co-receptors or as membrane bound ligands. In this report, we characterize the Gas1 domains required for its growth suppression function and demonstrate the dispensability of Gas1 GPI anchor. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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