期刊
SCIENCE
卷 289, 期 5486, 页码 1925-1928出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.289.5486.1925
关键词
-
The cellular prion protein PrPc is a glycosylphosphaltidylinositol-anchored cell-surface protein whose biological function is unclear: We used the murine 1C11 neuronal differentiation model to search for PrPc-dependent signal transduction through antibody-mediated cross-linking. A caveolin-1-dependent coupling of PrPc to the tyrosine kinase Fyn was observed. Clathrin might also contribute to this coupling. The ability of the 1C11 cell line to trigger PrPc-dependent Fyn activation was restricted to its fully differentiated serotonergic or noradrenergic progenies. Moreover, the signaling activity of PrPc occurred mainly at neurites. Thus, PrPc may be a signal transduction protein.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据