期刊
BRAIN RESEARCH
卷 877, 期 2, 页码 396-400出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(00)02710-4
关键词
multiple sclerosis; neurodegeneration; oligodendrocyte; footprint; Theiler's virus; motor function
资金
- NIMH NIH HHS [F31 MH012120] Funding Source: Medline
- NINDS NIH HHS [R01 NS024180, R01 NS24180, R01 NS3229, R01 NS032129] Funding Source: Medline
- PHS HHS [1F31ME12120] Funding Source: Medline
Identifying the role of axonal injury in the development of permanent, irreversible neurologic disability is important to the study of central nervous system (CNS) demyelinating diseases. Our understanding of neurologic dysfunction in demyelinating diseases and the ability to assess therapeutic interventions depends on the development of objective functional assays that can non-invasively measure axonal loss. In this study, we demonstrate in a murine model of progressive CNS demyelination that assessment of the hindlimb width of stride provides a powerful indicator of axonal loss and can dissociate between deficits induced by demyelination versus axonal loss. (C) 2000 Elsevier Science B.V. All rights reserved.
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