期刊
FEBS LETTERS
卷 481, 期 3, 页码 209-212出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)02006-8
关键词
AMP kinase; phosphoenolpyruvate carboxykinase; glucose; AICAR; hepatocyte
The effect of AMP-activated protein kinase (AMPK) in the regulation of the phosphoenolpyruvate carboxykinase (PEPCK) gene expression was studied in isolated rat hepatocytes, Activation of AMPK by AICAR counteracted the inhibitory effect of glucose on the PEPCK gene expression, both at the mRNA and the transcriptional levels. It is proposed that a target for AMPK is involved in the inhibitory effect of glucose on PEPCK gene transcription. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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