期刊
TETRAHEDRON LETTERS
卷 41, 期 39, 页码 7453-7456出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(00)01275-2
关键词
asymmetric addition; trimethylsilylcyanide; aldehydes; chiral nucleophiles; hypervalent silicon
Trimethylsilylcyanide has been added to a number of aldehydes using a highly active chiral catalyst. This procedure gives the TMS ethers of the corresponding cyanohydrins in excellent chemical yields with enantiomeric excesses of up to 59%. The reaction is believed to occur through hypervalent silicon intermediates. (C) 2000 Elsevier Science Ltd. All rights reserved.
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