期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 405, 期 1-3, 页码 263-275出版社
ELSEVIER
DOI: 10.1016/S0014-2999(00)00558-6
关键词
dopamine; microdialysis, in vivo; prefrontal cortex; shuttle-box; working memory; (gerbil)
This detailed analysis of behavior is aimed at the differentiation of the components of information processing during associative conditioning. In gerbils, the influences of various acquired non-avoidance strategies as pre-experience were studied during the learning of a standard avoidance task in the same shuttle-box. Identical cue stimuli, frequency-modulated tones as conditioned stimuli and electric footshocks as unconditioned stimuli, were used in various behavioral tasks. In addition to common parameters such as avoidance performance and reaction times, behavioral events such as the attention response and the orienting response were quantified. Thereby, components of shuttle-box learning such as signal detection and signal evaluation were found to be affected by pre-experience-dependent dynamics. Using a microdialysis technique during avoidance learning in the shuttle-box, we found that only strategy formation was correlated with high dopamine levels in medial prefrontal cortex. The increase in dopamine in medial prefrontal cortex may be an indicator of the involvement of working memory principles in signal evaluation stages of conditioning. (C) 2000 Elsevier Science B.V. All rights reserved.
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