期刊
CANCER LETTERS
卷 158, 期 1, 页码 103-108出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(00)00515-2
关键词
glioblastoma multiforme; signal transduction pathways; phosphatidylinositol-3 ' kinase; protein kinase B; Akt; mitogen-activated protein kinase
类别
We investigated the activation of two important signal transduction pathways in human glioblastoma cells and found a constitutive phosphorylation of either Akt or mitogen-activated protein kinase (MAPK) under serum free conditions. In all but one cell line Wortmannin-sensitive activation of Akt could be attributed to the loss of functional PTEN protein. All cell lines with Akt activation exhibited only weak phosphorylation of the MAPK signal pathway, whereas those without constitutive Akt activation demonstrated high levels of phosphorylated MAPK under serum free conditions. Our data might indicate the presence of two functional subtypes of glioblastoma multiforme, since Akt and MAPK are involved in cellular survival and proliferation signalling, respectively. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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