期刊
BIOLOGICAL CHEMISTRY
卷 395, 期 4, 页码 425-431出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2013-0293
关键词
cadmium toxicity; longevity; metal homeostasis; metal regulatory transcription factor; nuclear export signal (NES); zinc-induced transcription
资金
- Swiss National Science Foundation
- Kanton Zurich
The metal-responsive transcription factor-1 (MTF-1) is a key regulator of heavy metal homeostasis and detoxification. Here we characterize the first MTF-1 from a reptile, the slow worm Anguis fragilis. The slow worm, or blind worm, is a legless lizard also known for its long lifespan of up to several decades. Anguis MTF-1 performs well and matches the strong zinc and cadmium response of its human ortholog, clearly surpassing the activity of rodent MTF-1s. Some amino acid positions critical for metal response are the same in humans and slow worm but not in rodent MTF-1. This points to a divergent evolution of rodent MTF-1, and we speculate that rodents can afford a less sophisticated metal handling than humans and (some) reptiles.
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