期刊
BIOLOGICAL CHEMISTRY
卷 395, 期 5, 页码 545-558出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2013-0290
关键词
carbon dioxide; carbon monoxide; cobalt; energy coupling; nickel
资金
- German funding agency (DFG) [DO-785/1, DO-785/5]
- Cluster of Excellence 'Unifying Concepts in Catalysis-UniCat' [EXC 314]
The reductive acetyl-coenzyme A (acetyl-CoA) pathway, also known as the Wood-Ljungdahl pathway, allows reduction and condensation of two molecules of carbon dioxide (CO 2) to build the acetyl-group of acetylCoA. Productive utilization of CO 2 relies on a set of oxygen sensitive metalloenzymes exploiting the metal organic chemistry of nickel and cobalt to synthesize acetyl-CoA from activated one-carbon compounds. In addition to the central catalysts, CO dehydrogenase and acetyl-CoA synthase, ATPases are needed in the pathway. This allows the coupling of ATP binding and hydrolysis to electron transfer against a redox potential gradient and metal incorporation to (re) activate one of the central players of the pathway. This review gives an overview about our current knowledge on how these ATPases achieve their tasks of maturation and reductive activation.
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