期刊
BIOLOGICAL CHEMISTRY
卷 394, 期 9, 页码 1133-1143出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2013-0153
关键词
chemotherapy; kinase inhibitor; ribosome biogenesis; rRNA processing; tumor suppressor p53
资金
- Deutsche Forschungsgemeinschaft [SFB/TR5, SFB684]
The production and processing of ribosomal RNA is a complex and well-coordinated nucleolar process for ribosome biogenesis. Progress in understanding nucleolar structure and function has lead to the unexpected discovery of the nucleolus as a highly sensitive sensor of cellular stress and an important regulator of the tumor suppressor p53. Inhibition of ribosomal RNA metabolism has been shown to activate a signaling pathway for p53 induction. This review elucidates the potential of classical and recently developed chemotherapeutic drugs to stabilize p53 by inhibiting nucleolar functions.
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