期刊
BIOLOGICAL CHEMISTRY
卷 394, 期 7, 页码 857-863出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2013-0108
关键词
atherosclerosis; cancer; galectins; hemostasis; inflammation; platelets
资金
- National Agency for Promotion of Science and Technology (Argentina)
- National Council for Scientific and Technical Investigation (CONICET, Argentina)
- Sales Foundation for Cancer (Argentina)
- University of Buenos Aires (Argentina)
- National Multiple Sclerosis Society (USA)
Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug and is crucial for hemostasis. However, uncontrolled platelet activation may lead to the formation of occlusive thrombi. Several soluble or matricellular proteins can activate platelets. In this article, we review recent advances in knowledge of the role of galectins in platelet physiology. In soluble or immobilized form, these endogenous glycan-binding proteins trigger platelet activation through the modulation of discrete signaling pathways. We discuss the role of platelet-galectin interactions not only in hemostasis, but also in chronic inflammation, atherosclerosis and cancer.
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