期刊
BIOLOGICAL CHEMISTRY
卷 393, 期 8, 页码 661-673出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2012-0150
关键词
insects; molluscs; nematodes; N-linked oligosaccharides; protozoa; trematodes
资金
- Austrian Fonds zur Forderung der wissenschaftlichen Forschung [P13810, P15475, P17681, P18447, P19615, P20565, P23922, P21946]
- Austrian Science Fund (FWF) [P 21946, P 23922] Funding Source: researchfish
- Austrian Science Fund (FWF) [P15475, P13810, P17681, P18447, P19615, P20565, P23922] Funding Source: Austrian Science Fund (FWF)
Although countless genomes have now been sequenced, the glycomes of the vast majority of eukaryotes still present a series of unmapped frontiers. However, strides are being made in a few groups of invertebrate and unicellular organisms as regards their N-glycans and N-glycosylation pathways. Thereby, the traditional classification of glycan structures inevitably approaches its boundaries. Indeed, the glycomes of these organisms are rich in surprises, including a multitude of modifications of the core regions of N-glycans and unusual antennae. From the actually rather limited glycomic information we have, it is nevertheless obvious that the biotechnological, developmental and immunological relevance of these modifications, especially in insect cell lines, model organisms and parasites means that deciphering unusual glycomes is of more than just academic interest.
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