期刊
BIOLOGICAL CHEMISTRY
卷 393, 期 11, 页码 1279-1290出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2012-0199
关键词
bacteria; biogenesis; membrane protein insertion; mitochondria; targeting; thylakoids
资金
- European Science Foundation
- ALW
- Chemical Sciences Division of the Netherlands Foundation for Scientific Research
- Zernike Institute for Advanced Materials
The members of the YidC/Oxa1/Alb3 protein family are evolutionary conserved in all three domains of life. They facilitate the insertion of membrane proteins into bacterial, mitochondrial, and thylakoid membranes and have been implicated in membrane protein folding and complex formation. The major classes of substrates are small hydrophobic subunits of large energy-transducing complexes involved in respiration and light capturing. All YidC-like proteins share a conserved membrane region, whereas the N- and C-terminal regions are diverse and fulfill accessory functions in protein targeting.
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