期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 183, 期 4, 页码 1013-1022出版社
MOSBY-ELSEVIER
DOI: 10.1067/mob.2000.107321
关键词
intrauterine growth restriction; placenta; fetal brain damage; sheep
OBJECTIVE: Our aim was to determine the effects of 30 days of placental insufficiency on fetal brain development and to relate placental damage to the degree of fetal brain injury. STUDY DESIGN: Umbilicoplacental embolization was induced from 110 to 140 days of gestation (term, 147 days) in 7 fetal sheep, such that fetal arterial oxygen saturation was maintained at 50% of pre-umbilico-placental embolization values. Six control fetuses were used. At 140 days the fetal brains and placentas were subjected to structural and histochemical analysis. RESULTS: During umbilicoplacental embolization, fetal arterial oxygen saturation, PaO2, and pH were reduced (P < .05). Thirty days of umbilicoplacental embolization caused a decrease in cross-sectional area of the placentome (P < .05), with 20% of tissue showing damage, All umbilicoplacental embolization fetuses were growth restricted and had brain damage, most prominently in the cerebral white matter. There was no relation between the extent of placental damage and the severity of fetal brain damage. CONCLUSIONS: The absence of a correlation between damage to the placenta and fetal brain is likely to be caused by variations between individuals in (1) the amount of placenta that is required to be functionally damaged to achieve the prescribed level of hypoxemia and (2) the response of the fetal brain to that level of hypoxemia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据