期刊
BIOLOGICAL CHEMISTRY
卷 391, 期 5, 页码 505-511出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2010.056
关键词
cancer biomarkers; cancer prognosis; clinical outcome; KLKs; patient monitoring; PSA; treatment response
资金
- Ministry of Health and Social Solidarity of Greece [128635]
Tissue kallikrein (KLK1) and the kallikrein-related peptidase (KLK2-15) genes encode for a subgroup of 15 homologous secreted serine proteases possessing numerous physiological roles, such as the regulation of blood pressure, hormone processing and tissue remodeling. The expression of KLKs is detected in a broad spectrum of human tissues where it has been found to be regulated mainly by steroids hormones. The aberrant expression of KLKs, presented in many human malignancies, highlights the significance of this gene family for early diagnosis, prognosis and monitoring of cancer patients, as it is strongly emphasized by the routine use of PSA (KLK3) for prostate cancer management. Here, we review the presently known data regarding the role of KLKs as cancer biomarkers, giving emphasis on novel information about the subject.
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