期刊
BIOLOGICAL CHEMISTRY
卷 391, 期 7, 页码 771-776出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2010.078
关键词
selenium; selenocysteine tRNA; Sep-tRNA:Sec-tRNA synthase; Soluble Liver Antigen/Liver Pancreas; stop codon recoding; UGA recoding
资金
- Department of Energy
- National Institute for General Medical Sciences
- National Science Foundation
- Yale University School of Medicine
Selenocysteine, the 21st genetically encoded amino acid, is the major form of the antioxidant trace element selenium in the human body. In eukaryotes and archaea its synthesis proceeds through a phosphorylated intermediate in a tRNA-dependent fashion. The final step of selenocysteine formation is catalyzed by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SepSecS) that converts phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec). The human SepSecS protein is also known as soluble liver antigen/liver pancreas (SLA/LP), which represents one of the antigens of autoimmune hepatitis. Here we review the discovery of human SepSecS and the current understanding of the immunogenicity of SLA/LP in autoimmune hepatitis.
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