期刊
BIOLOGICAL CHEMISTRY
卷 390, 期 4, 页码 287-293出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2009.035
关键词
apolipoprotein E; ATP-binding cassette transporters; blood-brain barrier; cerebellum; Niemann-Pick type C; oxysterols; 24(S)-hydroxycholesterol; 27-hydroxycholesterol
资金
- National Heart, Lung and Blood Institute [R01 HL009610]
- Moss Heart Fund
- Ara Parseghian Foundation
- Dana's Angels Research Medical Trust
The average amount of cholesterol in the whole animal equals approximately 2100 mg/kg body weight, and 15% and 23% of this sterol in the mouse and human, respectively, is found in the central nervous system. There is no detectable uptake across the blood-brain barrier of cholesterol carried in lipoproteins in the plasma, even in the newborn. However, high rates of de novo cholesterol synthesis in the glia and neurons provide the sterol necessary for early brain development. Once a stable brain size is achieved in the adult, cholesterol synthesis continues, albeit at a much lower rate, and this synthesis is just balanced by the excretion of an equal amount of sterol, either as 24(S)-hydroxycholesterol or, presumably, as cholesterol itself.
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