期刊
BIOLOGICAL CHEMISTRY
卷 390, 期 7, 页码 567-574出版社
WALTER DE GRUYTER & CO
DOI: 10.1515/BC.2009.078
关键词
axon guidance; brain connectivity; cell-cell interaction; cell surface glycosylation; neural cell adhesion molecule NCAM; polysialyltransferase
资金
- Deutsche Forschungsgemeinschaft DFG [Hi 678/3, MU 1774/1, RGS 801/6, 801/10]
- Deutsche Krebshilfe DKH [107002, 106969]
- Sixth Framework Program of the European Commission [FP6 512012]
Polysialic acid (polySia) is a major regulator of cell-cell interactions in the developing nervous system and a key factor in maintaining neural plasticity. As a polyanionic molecule with high water binding capacity, polySia increases the intercellular space and creates conditions that are permissive for cellular plasticity. While the prevailing model highlights polySia as a non-specific regulator of cell-cell contacts, this review concentrates on recent studies in knockout mice indicating that a crucial function of polySia resides in controlling interactions mediated by its predominant protein carrier, the neural cell adhesion molecule NCAM.
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