A young female with asymmetric manifestations of Larsen syndrome: another example of unilateral somatic cell-line mosaicism

Larsen syndrome is characterized by multiple congenital joint dislocations, typical skeletal defects and facial dysmorphism. In this article, we present a female patient with asymmetric Larsen syndrome. We hypothesise that the asymmetric distribution of clinical features in our patient is likely caused by post-zygotic somatic cell-line mosaicism of a dominant gene mutation. Clin Dysmorphol 9: 273-276 (C) 2000 Lippincott Williams & Wilkins.