期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 67, 期 2, 页码 265-270出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0091-3057(00)00359-2
关键词
CB1; SR141716A; WIN 55,212-2; food-maintained responding; fixed-ratio schedule; FR 15; isobologram
资金
- NIDA NIH HHS [P50DA06634, F31DA05940] Funding Source: Medline
previous reports have indicated that administration of the central cannabinoid receptor (CBI) antagonist SRI41716A decreases intake of highly palatable food and drink. Disruption of normal food intake has been reported only at high doses known to disrupt spontaneous behaviors. The present study was designed to determine if rates of responding for normal food were sensitive to the effects of cannabinoid receptor blockade. Adult, male Sprague-DawIey rats were trained to lever press for normal food pellets under a fixed-ratio 15 (FR 15) schedule of reinforcement. SR141716A (0.3-3.0 mg/kg) produced dose-dependent reductions in response rate. WIN 55,2 12-2 (0.3 mg/kg), a high efficacy cannabinoid agonist, given as a pre-treatment to SR141716A, significantly attenuated the rate-suppressing effects of SR141716A, suggesting a principal role of CB1 receptors in mediating these behavioral effects. These data indicate that high palatability is not necessary to observe an anorectic effect of SR141716A. (C) 2000 Elsevier Science Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据