Short stature and coronary heart disease:: a 35-year follow-up of the Finnish cohorts of The Seven Countries Study

Objectives. To examine whether short stature is associated with an increased risk of coronary heart disease. Design. Follow-up study. Setting. Two geographically defined areas in eastern and western Finland. Subjects. A total of 1441 men who were free of coronary heart disease at the start of the follow-up. Main outcome measures. Hazard ratios for fatal and non-fatal coronary heart disease Results. Height was inversely related to fatal coronary heart disease and incident non-fatal coronary heart disease during the follow-up. These relationships persisted after adjusting for other major cardiovascular risk factors. Comparing the high-risk area in eastern Finland with the low-risk area in south-western Finland, no difference in fatal coronary heart disease and cumulative incidence of non-fatal coronary heart disease was seen in tall men. The increase in risk of coronary heart disease death was 19% for a 10 cm decrease in height (OR = 0.81, 95% CI = 0.68-0.95). Conclusions. Our results show that short stature is an independent risk factor for coronary heart disease. Differences in stature partly explain the Finnish east-west difference in the incidence of coronary heart disease.